Each film coated tablet contains Memantine HCl INN 5mg.
Persistent activation of central nervous system N-methyl-D-aspartate (NMDA) receptors bythe excitatory amino acid glutamate has been hypothesized to contribute to thesymptomatology of Alzheimer`s disease. Memantine is postulated to exert its therapeuticeffect through its action as a low to moderate affinity uncompetitive (open-channel) NMDAreceptor antagonist which binds preferentially to the NMDA receptor-operated cationchannels
Memogen (Memantine Hydrochloride) is indicated for the treatment of moderate to severedementia of the Alzheimer\'s type.
The recommended starting dose of Memogen is 5 mg once daily. The recommended targetdose is 20 mg/day. The dose should be increased in 5 mg increments to 10 mg/day (5 mgtwice a day), 15 mg/day (5 mg three times a day) and 20 mg/day (5 mg four times a day).The minimum recommended interval between dose increase is one week.
Memantine hydrochloride is contraindicated in patients with known hypersensitivity toMemantine hydrochloride or to any excipients used in the formulation.
Caregivers should be instructed in the recommended administration (twice per day fordoses above 5 mg) and dose escalation (minimum interval of one week between doseincreases).
Pregnancy Category B.There are no adequate and well-controlled studies of Memantine in pregnant women.Memantine should be used during pregnancy only if the potential benefit justifies thepotential risk to the fetus.It is not known whether Memantine is excreted in human breast milk. Because many drugsare excreted in human milk, caution should be exercised when Memantine is administeredto a nursing mother.
Amantadine, Anticholinergics, Anticonvulsants, Baclofen, Barbiturates, Cimetidine,Dantrolene, Dextromethorphan, Dopaminergic, Hydrochlorothiazide, Ketamine,Neuroleptics, Nicotine, Procainamide, Quinidine, Quinine & Ranitidine.
Most common side effects (frequency of 2% or less) include hallucinations, confusion,dizziness, headache and fatigue. Occasional side effects include anxiety, hypertonus(heightened muscle tension), vomiting, bladder infections and increased sexual drive.
Memogen Tablet: Each box containing 3x10 tablets in blister pack.
