Rivo 0.5 Tablet : Each tablet contains Clonazepam USP 0.5 mg. Rivo 2 Tablet : Each tablet contains Clonazepam USP 2 mg.
Rivo (Clonazepam) potentiates the pre - and post synaptic inhibitory action of GABA in the CNS. Over compensatory excitation processes are thereby reduced via negative feedback without substantial disturbance of other physiological neuronal activity. Rivo is rapidly and well absorbed following oral administration. The plasma half-life of Rivo is relatively long and varies from individual to individual. Rivo is distributed extensively throughout the
body. It is mainly metabolized in liver. Upto 70 % of the metabolite is excreted by the urine and 30 % in the feces.
Rivo 0.5 Tablet : Each tablet contains Clonazepam USP 0.5 mg.Rivo 2 Tablet : Each tablet contains Clonazepam USP 2 mg.
1. Panic attack2. Epilepsy (Status epilepticus, Lennox-Gastaut syndrome, Infantile spasm, Absence seizure, Myoclonic seizure, Tonic-clonic seizure, Akinetic and atonic seizure, Partial seizure)3. Bipolar affective disorder 4. Drug-induced dyskinesia5. Choreiform movement6. Fulgurant pain 7. Tourette\'s syndrome 8. Resistant depression 9. Nocturnal myoclonus 10. Trigeminal neuralgia
Infants and children Up to 1 year : 0.25 mg daily in divided dose, increase gradually to 0.5 - 1 mg. 1 - 5 years : 0.25 mg daily in divided dose, increase to 1 - 3 mg. 5 - 12 years : 0.5 mg daily in divided dose, increase to 3 - 6 mg.Adults and elderly Initial dose : 1 mg daily in divided dose (Elderly 0.5 mg), not to exceed 1.5 mg/day Increment dose : 0.5 - 1 mg at intervals of 3 days Maintenance dose : 4 - 8 mg/day Maximum dose : 20 mg/day should be administered with caution Dosing interval : b.i.d./t.i.d.Initial dose should be low and increased gradually to a maintenance dose that controls seizure without toxic effects. During discontinuation, the dose should be tapered.
Clonazepam should not be used in patients with a history of sensitivity to benzodiazepine, nor in patients with clinical or biochemical evidence of significant liver disease. It may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow angle glaucoma.
When used in patients in whom several different types of seizure disorders coexist,Clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonicseizures (grand mal). This may require the addition of appropriate anticonvulsants or anincrease in their dosages. The concomitant use of valproic acid and Clonazepam mayproduce absence status. Periodic blood counts and liver function tests are advisable duringlong term therapy with Clonazepam. The abrupt withdrawal of Clonazepam, particularly in those patients on long-term, highdosetherapy, may precipitate status epilepticus. Therefore when discontinuing Clonazepam, gradual withdrawal is essential. Clonazepam may produce an increase in salivation. This should be considered before givingthe drug to patients who have difficulty handling secretions. Because of this and the possibility of respiratory depression, Clonazepam should be used with caution in patients with chronic respiratory diseases. Because of the possibility that adverse effects on physical or mental development couldbecome apparent only after many years, a benefit-risk consideration of the long-term use of clonazepam is important in pediatric patients.
Pregnancy Category-D. The use of Clonazepam during pregnancy or lactation should beavoided. Clonazepam is excreted into the breast milk and should therefore be avoided in breast-feeding mothers.
The CNS-depressant action of the benzodiazepine class of drugs may be potentiated byalcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.
The most frequently occurring side effects of Clonazepam are referable to CNS depression, drowsiness, fatigue, dizziness, muscle hypotonia, co-ordination disturbance, hypersalivation in infants, paradoxical aggression, irritability and mental change.
Symptoms of Clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.
Rivo 0.5 Tablet : Each box contains 5 blister strips of 10 tablets.Rivo 2 Tablet : Each box contains 3 blister strips of 10 tablets.
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