Preparation
Truso-200 Capsule: Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.
Truso-400 Capsule: Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 400 mg.
Truso Powder for Suspension (37.5 ml & 50 ml): After reconstitution, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 100 mg.
Truso DS Powder for Suspension (50 ml): After reconstitution, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.
Truso Pediatric Drops (15 ml): After reconstitution, each 1 ml contains Cefixime Trihydrate USP equivalent to Cefixime 25 mg.
Therapeutic Class
Third Generation Cephalosporin Antibiotics
Indication
Truso is indicated in the treatment of following infections caused by susceptible microorganisms:
Upper respiratory tract infections: Otitis media, and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics.
Lower respiratory tract infections: Bronchitis
Urinary tract infections: Cystitis, Cystourethritis, pyelonephritis, gonococcal urethritis.
Gonorrhoea (Uncomplicated)
Typhoid fever
Contraindication
Truso is contraindicated in patients with known hypersensitivity to the Cephalosporin antibiotics.
Dosage & Administration
Truso Capsule:
Adult and children over 10 years: 200-400 mg daily 1-2 divided doses for 7 to 14 days.
Gonorrhoea: 400 mg as a single dose.
Truso powder for suspension, Truso DS powder for suspension and Truso pediatric drops:
Children over 6 months: 8 mg/kg body weight daily in 1-2 divided doses for 7 to 14 days or
6 months - 1 year : 75 mg daily for 7-14 days
1 - 4 years : 100 mg daily for 7-14 days
5 - 10 years : 200 mg daily for 7-14 days
Typhoid fever : 20 mg/kg body weight daily in 2 divided doses for 10 days
Side Effect
Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials were mild and self-limiting in nature. Diarrhoea, changes in the colour of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, dizziness have been reported.
Precaution
Cephalosporin should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and cephalosporins. Cefixime should be administered with caution in patients with markedly impaired renal function. In patients whose creatinine clearance is less than 20 ml/min, it is recommended that a dose of 200 mg once daily should not be exceeded.
Drug Interaction
Elevated carbamazepine levels have been reported. Increase prothrombin time with or without clinical bleeding has been reported when cefixime is administered concomitantly with warfarin and anticoagulants.
Presentation
Truso-200 mg capsule: Box containing 3x6\'s capsules in blister pack.
Truso-400 mg capsule: Box containing 2x4\'s capsules in blister pack.
Truso Powder for Suspension (37.5 ml & 50 ml): After reconstitution each bottle contains 37.5 ml or 50 ml suspension.
Truso DS Powder for Suspension: After reconstitution each bottle contains 50 ml suspension.
Truso Pediatric Drops: After reconstitution each bottle contains 15 ml Pediatric drops.
