Preparation
Axofyl 200 Tablet: Each film coated tablet contains Doxofylline INN 200 mg.
Indication
Axofyl is used to treat asthma, COPD and bronchospasm.
Contraindication
Doxofylline is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components.
Dosage & Administration
Adults: Doxofylline 400 mg (1 tablet) daily in the evening. However, in certain cases 400 mg twice daily is recommended on the basis of the clinical response. Doses as high as 1200 mg/day (400 mg 3 times daily) may also prescribed. In elderly patients with concomitant cardiovascular, hepatic and renal diseases recommended dosage should be 200 mg twice daily.
Children (above 6 years of age): The recommended dosage of Doxofylline is 6 mg/kg twice daily. The dose may be increased up to 18 mg/kg daily on the basis of clinical response.
Side Effect
Doxofylline rarely causes serious side effects, however possible side effects are similar of taking excess amount of caffeine. These include: nausea, vomiting, headaches, upset stomach and heartburn.
Precaution
The half-life (t1/2) of xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol and anti-flu vaccine. In these cases, a lower dose of Doxofylline may be needed. Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life (t1/2). In these cases higher doses of Doxofylline may be needed.
Drug Interaction
Doxofylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant therapy with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol and anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels. No evidence of a relationship between Doxofylline serum concentrations and toxic events have been reported.
Presentation
Axofyl 200 Tablet: Each box contains 3x10 tablets in Alu-PVDC blister pack.
Contraindications
Doxofylline is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components.
Use Children
Doxofylline should be administered cautiously to young children.
Use Pregnancy Lactation
Animal reproduction studies indicate that, Doxofylline does not cause fetal harm when administered to pregnant animals or can not affect reproduction capacity. However, since there is limited experience in human during pregnancy, Xanthines should be given to pregnant women only if clearly needed. Doxofylline is contraindicated in nursing mothers.
Overdosage
Although no major arrhythmias have been documented with Doxofylline tablets the occurrence of major cardiac rhythm disturbances cannot be excluded in case of overdosage of xanthine compounds. If a potential oral overdose is established the patient may present with seizures; these symptoms could be the first sign of intoxication. Adverse reactions may cause the withdrawal from treatment. A lower dose may start only after the advice of the physician. There is no specific antidote. Doxofylline tablets does not cause any risk of tolerance or addiction.
Storage
Store in a cool & dry place, protected from light. Store below 30 ºC. Keep all medicines out of the reach of children.